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Bazot, M., Bharwani, N., Huchon, C., Kinkel, K., Cunha, T

The modified residues are often (but not always) situated within specific protein domains called Gla domains

After reaching the 1mg maintenance phase, some patients may increase to 1.5mg or 2.4mg weekly based on clinical goals and tolerability

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In contrast to human tissue and cultured cells, it has been demonstrated that Nrf2 activity is consistently elevated in the spinal cord of SOD1 G93A rodent models of ALS, and the increase of Nrf2, thioredoxin, HSP-70, HO1, NQO1, GCLC, and GCLM protein levels follows disease progression in the lumbar spinal cord but not cortex [264, 265]