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Place the Jelly side of the pad on the skin and leave it for 3-5 mins

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176 In particular, C18- and C16-long-chain ceramides that are produced by ceramide synthase isoforms (CerS1, CerS5, and CerS6) have higher concentrations in insulin-resistant tissues

If your medication gets warm or accidentally freezes, do not use it until you confirm with your pharmacy