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The limit for molecular area appears to be around 80 2 , and increases in size to greater than this seem to decrease BBB permeability dramatically

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In addition, the Connectivity Map gene profiling software developed by the Broad Institute, showed that out of several thousand biological molecules, the naturally occurring peptide glycyl-L-histidyl-L-lysine (GHK), in its Cu-bound form prevented impaired TGF1 signaling [4], a pathway associated with A deposition and neurofibrillary tangle formation [5]

Acknowledgments This study received financial support from Fundao de Amparo a Pesquisa de Gois (FAPEG), Coordenao de Aperfeioamento de Pessoal de Nvel Superior (CAPES), and Conselho Nacional do Desenvolvimento Cientfico e Tecnolgico (CNPq)

Geriatr Gerontol Int 20(2):97100