Anything beyond that needs stronger evidence
These reactions are driven by dysregulated B and T cells and involve several cytokines, including interferons (type 1 and 2) and ILs
We extracted data on first author, PubMed identification number, publication year, country of origin of the participants, study design, cohort name/or data source, the country of origin, the date of recruitments, study primary question, the number of participants, the type of cancer, age, sex, the follow up time in longitudinal or treatment studies, plasma B12 concentrations or other B12 markers measured in patients/controls, the inclusion and exclusion criteria of the original studies, B12 analytical method, effect size (i.e., RR, OR, HR), what was considered as exposed/not exposed, reference categories, and key results
Any pharmacy would also need to evaluate the final federal action, applicable state law, the exact substance and formulation, patient-specific prescription requirements, sourcing, and other compounding standards before dispensing a medication
Thaler FJ, Michalopoulos GK