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Among them, APOL1 was a protective gene, and DIRAS3, NAMPT, P4HB and SPHK1 were considered high-risk genes for poor prognosis in BC

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Case series 1: Under medical oversight, two individuals with Bardet-Biedl syndrome and type 2 diabetes mellitus lost 15% of their total body weight in a 3- and 5-month period, respectively, following a combination therapy of tirzepatide and setmelanotide

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Historical comparison: Lifestyle-based blockbusters like Viagra and Prozac, once considered industry-shaping, fall far short of the scale and speed of revenue achieved by these GLP-1 products