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Furthermore, a study in CKD rat models, a 5/6 nephrectomy (5/6 Nx) model and an adenine model, respectively, showed that the level of renal NAD + and NADH as well as the expression of the three key enzymes in NAD + biosynthesis, QPRT, and NMNAT1/3 was significantly downregulated in the kidney of the two CKD models

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