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These techniques harness the principle that functionally competent spermatozoa are endowed with HA binding sites that permit their adherence to, and digestion of, the HA-rich cumulus oophorus matrix ( In terms of offering a biological explanation for the lack of consensus regarding the clinical outcomes of sperm selection achieved using HA-based systems, there is now compelling evidence that the surface architecture of a human spermatozoon undergoes a substantial capacitation-associated remodeling in preparation of oocyte interaction ( M1

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