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This disconnect limits the ability to determine whether observed benefits truly reflect restoration of redox homeostasis or arise from unrelated mechanisms

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Their activation is triggered by the recognition of pathogen-associated molecular patterns (PAMPs), such as bacterial flagellin, and damage-associated molecular patterns (DAMPs), including uric acid crystals

Dehydration from severe nausea, vomiting, or diarrhea can cause acute kidney injury, with or without existing kidney disease [131], as well as heart palpitations, so efforts should be made to prevent dehydration

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