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This section also provides estimates of total mortality from smoking from 1960 to 2020 in the three countries (totalling about 41 million deaths), including the relationship of number of cigarettes smoked with mortality

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E-cigarettes contain substances such as nicotine, glycerol, propylene glycol, flavorings, and metal particles, which can activate macrophages and cause endothelial dysfunction, leading to inflammation and oxidative stress