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D., OLoughlin, J

Paradoxically, this chronic inflammation does not improve immune protection it exhausts the inflammatory response system, leading to what immunologists call "immune exhaustion." The immune system is perpetually activated but progressively less able to mount a focused, effective response to specific new threats

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[b] [37] [38] No Smoking received negative reviews from critics, with many dismissing it as self-indulgent and confusing, though international reviews were considerably positive