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As far as medical issues go, I dont think there is a single surgery on the planet that has the potential for such a huge improvement in quality of life with such little hassle or discomfort for the patient

Edaravone (Radicava) was approved by the FDA in 2017 to treat ALS patients (FDA 2017)

Afzal, S

[DOI] [PMC free article] [PubMed] [Google Scholar] Kisling A, Byrne S, Parekh RU, Melit-Thomas D, de Castro Brs LE, Lust RM, Clemens S, Sriramula S, Katwa LC (2021) Loss of function in dopamine D3 receptor attenuates left ventricular cardiac fibroblast migration and proliferation in vitro

Mar 2012;142(3):513-519