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High dietary fat intake induces a microbiota signature that promotes food allergy
NAD+ supports mitochondrial function and DNA repair across all cell types, including neurons
its blockade increases serotonin release Promotes neurogenesis : TREK-1 knockout mice show increased hippocampal neurogenesis, and PE-22-28 recapitulates this effect pharmacologically within 4 days of treatment Induces synaptogenesis : TREK-1 blockade promotes dendritic growth and synaptic connection formation PE-22-28 inhibits TREK-1 with an IC50 of 0.12 nM, making it approximately 300-500 times more potent than spadin
Pain Modulation: DSIP is hypothesized to have analgesic-like properties, possibly by influencing opioid receptor activity and modulating pain signal transmission pathways
TB-500 also demonstrates potent anti-inflammatory properties by modulating the nuclear factor-kappa B (NF-B) pathway, reducing the production of pro-inflammatory cytokines
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