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Adipocyte Metabolism and Function Research Laboratory studies investigate AOD9604s effects on adipocyte biology: Lipogenesis Inhibition: Examination of de novo lipogenesis suppression, ACC inhibition, FAS expression Fatty Acid Oxidation: Research on -oxidation enhancement, CPT1 activity, mitochondrial function Adipocyte Differentiation: Studies on preadipocyte differentiation, PPAR expression, adipogenesis Metabolic Gene Expression: Investigation of transcriptional programs affecting lipid metabolism Inflammatory Markers: Research on cytokine expression, macrophage infiltration, inflammatory signaling Experimental models include 3T3-L1 adipocyte differentiation, primary adipocyte cultures, and adipose tissue explants
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Cell culture studies demonstrate stimulation of beta-3 adrenergic receptors in adipocytes, enhancing fat oxidation while inhibiting lipogenesis via acetyl CoA carboxylase blockade
[DOI] [PubMed] [Google Scholar] 170.Tlak Gajger I., Smodis Skerl M.I., Sostaric P., Suran J., Sikiric P., Vlainic J
