FDA-approved indications for bevacizumab (Avastin) include: Metastatic colorectal cancer (mCRC), first- and second-line Non-squamous non-small cell lung cancer (NSCLC), first-line Glioblastoma (GBM), recurrent Metastatic renal cell carcinoma (mRCC) Persistent, recurrent, or metastatic cervical cancer Platinum-resistant recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer Platinum-sensitive recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer Hepatocellular carcinoma (HCC), unresectable Endometrial carcinoma (certain combinations) Colorectal cancer, the most common bevacizumab indication, is typically confirmed through a diagnostic colonoscopy such as 45378 before staging establishes metastatic disease and bevacizumab therapy begins
doi: 10.1038/43710 50 FischerA.SananbenesiF.WangX.DobbinM.TsaiL
Drug Resist Updat 7, 97110
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