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However, within the cell, in the cytosol and mitochondria, the GPx system appears to be very efficient in the elimination of H 2 O 2 due to the low (100200 M) K m value of the enzyme [136] and the range of substrates [137]

PWL was defined as the time that it took the rat to exhibit pain-related behaviors, such as paw licking, hindlimb withdrawal, or jumping, obtained from three repeats of the experiment (5 min intervals) after being placed on the hot plate surface at 52 0.5C

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