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Lisofylline, a fat metabolism inhibitor which prevents buildup of ceramide a by product of fat metabolism in mouse skeletal muscle decreased the insulin resistance and thus appears to be a novel new approach for type 2 diabetes [141]

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immune cells are among the most GSH-dependent in the body Redox signalling the GSH/GSSG (reduced/oxidised) ratio is a master regulator of cellular redox state, modulating transcription factors including NF-B and Nrf2 Protein maintenance glutathionylation protects cysteine residues in proteins from irreversible oxidation, preserving enzyme function Glutathione levels decline with age, chronic illness, toxin exposure, and oxidative stress contributing to accelerated cellular aging, impaired detoxification, and systemic inflammation