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This distinction is part of why recomposition-focused research is generally structured around peptide pairings rather than single-compound protocols, since no one mechanism has been shown in the literature to independently account for both outcomes

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ES2 is a senolytic peptide that targets FOXO4 CR3 but exhibits relatively poorer selectivity for senescent cells compared to FOXO4-DRI 25 (Table S1)

More comprehensive human studies are needed to validate and fully understand these benefits