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(Weinh) 12 (31), e02830

Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome independently of energy intake

Psychiatry 20 , 661670 (2015)

10.1111/bph.13426 112 WongK

MOTS-c has a short half-life (46 hours), so missing a single dose doesn't create long-term metabolic disruption, but it does interrupt the AMPK activation pattern for that 48-hour window