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Surprisingly, 5 m fisetin slightly increased the content of spontaneous melanin and extracellular melanin, fisetin (at 20 m) markedly increased the content and release of melanin in B16F10 cells by up regulating the expression of TYR and MITF, and promoted the melanin synthesis of zebrafish larvae

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While these symptoms have many potential causes, they require evaluation to rule out thyroid pathology, given the FDA's boxed warning regarding thyroid C-cell tumors

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