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Discussion The BBB poses a significant impediment to drug delivery, with over 98% of pharmaceutical agents unable to efficiently traverse it, thereby diminishing their therapeutic efficacy in treating various neurological disorders, including neurodegenerative diseases 35

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Although further clinical and deep molecular studies are required before transposing to humans, our study emphasized DAPAs potential to relieve hyperthyroidism-induced cardiopulmonary injury in rats through its antioxidant, anti-inflammatory, and anti-apoptotic effects, as well as via antagonizing the sympathetic over activity

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