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GLP-1 dose increases can only take you so far

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placebo at 68 weeks in 667 patients with a mean age of 50 years, mostly females, with a mean BMI of 37.5 kg/m 2 and dysglycemia in 8% participants (BW reduction 15.1% vs

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Liraglutide, semaglutide and tirzepatide are incretin-based therapies currently approved by FDA for the management of obesity, while triple GIPR/GCGR/GLP-1R agonist retatrutide (LY3437943), the cagrilintide/semaglutide (CagriSema) 2.4 mg combination, high-dose oral semaglutide, and oral orforglipron are in advanced stages of development