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In a phase 3 clinical trial, people taking 50 milligrams of oral semaglutide lost an average of 15.1% of their body weight in 68 weeks

Donanemab in early symptomatic Alzheimer disease: the TRAILBLAZER-ALZ 2 randomized clinical trial

Gallbladder Problems Rapid weight loss increases the risk of gallstones, which can lead to gallbladder inflammation (cholecystitis)

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects

Unlike some weight loss medications that require daily administration or strict timing around meals, semaglutide is injected just once a week