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38 Autophagy adapters are defined as proteins possessing both a ubiquitin-binding domain (UBD) that recognizes ubiquitin-tagged mitochondria and an LC3 interacting region (LIR) that interacts with ATG8 family proteins, which mainly includes sequestosome 1 (P62/SQSTM1), 39 neighbor of BRCA1 gene 1 (NBR1), 40 nuclear dot protein 52 (NDP52/CALCOCO2), 41 human T-cell leukemia virus type I binding protein 1 (TAX1BP1), 42 and optineurin (OPTN)

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