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The workup includes thyroid panel (often the most-skipped contributor), hormone evaluation (perimenopause, menopause, low testosterone), insulin and inflammation markers, sleep evaluation, stress and HPA-axis context, and gut function review

This is important for people with Type 2 diabetes and chronic kidney disease

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Ther.: Methods Clin

Background and Summary of Retrospective Studies Homocystinuria caused by congenital CBS and MTHFR defects or by genetic alteration of cobalamin metabolism is characterized by clinical problems including frequent arterial and venous thromboembolism and premature atherosclerosis (McCully, 1983