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Absolute contraindications: Wilson's disease or any other copper metabolism disorder, active cancer (because of GHK-Cu's pro-angiogenic activity), pregnancy, and breastfeeding

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The heavy methylation of its promoter has been observed

The mechanism is to promote melanin synthesis by increasing the phosphorylation level of p38 MAPK, which in turn increases the expression of MITF and tyrosinase ( Berberine Berberine (BBR, (Figure 7C) natural isoquinoline alkaloid, is a major compound isolated from the Chinese herb Coptis chinensis Franch

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