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this association is dosedependent and it remains significant even after adjusting for confounding factors temporal relationship: smoking has been prospectively associated with the occurrence of schizophrenia and this association remains significant after adjusting for the prodromal period of the illness consistency: the association has been shown to be present across many countries, over time and in a variety of settings plausible mechanism: neurobiological research supports the hypothesis of stimulation of nicotinic receptors on dopaminergic neurons in the midbrain, which induces increased dopamine release in the nucleus accumbens