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Although long duration has persistent cumulative effects, a large proportion of the risk seems to occur in the short term.91 Fourthly, some heavy smokers could misreport as light smokers at baseline (or vice versa, although few like this are expected), but if this represented a substantial proportion there would probably be non-linear associations between consumption and the risk of other disorders (for example, lung cancer), which is generally not seen in large studies.101755 However, self reported smoking status has been shown to be acceptable, at least in older observational studies.92 Even if we assumed that misclassification was so extreme that it halved the excess risk for coronary heart disease for one cigarette per day (from table 1, 24% for men where relative risk=1.48 and 29% for women where relative risk=1.57), these estimates would still be substantially higher than the 5% expected if assuming a linear relation with risk

Unless pending lawsuits end up forcing the FDA to change the language of its e-cigarette regulations, virtually every e-cigarette on the market will need FDA approval to remain in the market by the end of 2018

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