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Skeletal muscle is the major tissue responsible for insulin-mediated glucose disposal, accounting for approximately 85% of all postprandial glucose uptake (101)

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DNA methylation, particularly in CpG islands, regulates gene expression, with hypomethylation in synovial fibroblasts and peripheral blood mononuclear cells (PBMCs) contributing to inflammation and joint damage

Rapamycin (starting at $65/month): Manufactured in FDA-registered facilities as an immunosuppressant for organ transplant recipients, rapamycin is presented by the company within a longevity context that the platform states requires ongoing monitoring and blood work