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Some oral formulations can help, but they require exact administration rules and may produce smaller systemic levels

Tirzepatide carries a similar gastrointestinal side effect profile to semaglutide, though some patients report milder nausea

These enhancements were speculated to be a direct effect of liraglutide, rather than an effect of decreased blood glucose, which was achieved by dapagliflozin and acarbose [91]