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Retatrutide improved fasting lipid profiles including triglycerides, very low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol in clinical trials in people with T2D or obesity, while low-density lipoprotein cholesterol was reduced in people with obesity 12,13,28

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During the process of follicular atresia, the accumulation of autophagosomes once reaching a certain level can induce apoptosis in GCs