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That asset, LY3884963, came to the company from Prevail Therapeutics, which Lilly swallowed for $1.04 billion in December 2020

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It cites weight loss of 5 to 10% as enough to reduce lupus activity scores and improve response to disease-modifying medication

This instability is primarily attributed to tautomerization, a process in which curcumin can exist in two forms: enol and keto (Figure 1C)