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In 2023, the FDA launched an investigation after GLP-1 agonist users started reporting thoughts of suicide as of January 2024, it hadnt found anything to confirm the connection, but it also said it couldnt yet rule it out, meaning its possible the drugs could cause mental health issues for some people, rather than treating or preventing them
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This finding ran counter to the researchers initial expectations that individuals at a higher weight would be most stigmatized, and suggests that medication-assisted weight loss may be perceived by some as socially undesirable or morally questionable, despite its medical effectiveness
There is a lack of good quality clinical evidence that older people have a clinically significant difference in paracetamol metabolism or are at increased risk of toxicity at either therapeutic or supra-therapeutic doses