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When comparing the effect sizes to the risk of bias assigned in the quality assessment, most of the interventions with low and moderate effect size both have been qualified as interventions with low risk of bias

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When there were multiple reports of a same study, publication with the longest follow-up period or the largest event numbers was selected for estimation of pooled RRs, to avoid bias

In fact, the FDA has sent warning letters to certain manufacturers of new oral nicotine products, declaring them in violation of federal law for implying or explicitly stating that their product is lower risk