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Similarly, the association of CR levels with a purine/pyrimidine bias suggests that CR hi tumors are also likely to be sensitive to existing nucleotide imbalancetargeting therapeutics such as methotrexate, whereas pyrimidine synthesistargeting therapeutics such as pemetrexed and 5-fluorouracil (55) are likely to be more effective in CR hi HCC tumors

In North America, the commercial launch of IQOS in Austin in March 2025 and the April 2026 FDA MRTP reauthorization have strengthened the category's foundation

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