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However, a detailed mechanistic understanding of GLP-1R activation linked to downstream signalling is still lacking, with the existing structural information unable to fully explain how differential peptide efficacies arise, or the differential requirements of the N-terminus and C-terminal sequences of peptide analogues

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For medical clinicians aiming to discuss general wellness and holistic disease management with their patients, framing curcumin as a targeted, evidence-based intervention provides a highly valuable, non-pharmacological tool