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Revolutionary NNMT Inhibition Mechanism 5-Amino-1MQ functions as a potent selective inhibitor of nicotinamide N-methyltransferase with IC = 1M, preventing the enzyme from converting nicotinamide to 1-methylnicotinamide

However, these parameters derive entirely from animal studies, and optimal human administration strategies remain undefined

Notably, these changes correlate with decreased circulating GH and IGF-1 levels in female, but not male, rats

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