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Rheum officinale enema can also reduce TMAO and TMA levels in the serum of 5/6Nx CKD rats by decreasing certain TMAO-related bacteria, inhibit the expression of inflammatory markers (interleukin-6, tumour necrosis factor-, and interferon-), alleviate renal interstitial fibrosis, and slow the progression of CKD ( Cornus officinalis Siebold and Zucc

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