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10.1016/S0006-2952(97)00014-2 53 YangJ.JameiM.HeydariA.YeoK

Molecular Structure GHK-Cu is a tripeptide-copper complex with the following structural characteristics: Sequence : Glycyl-L-histidyl-L-lysine (3 amino acids) Molecular weight (free peptide) : ~340 Da Molecular weight (copper complex) : ~400 Da Copper binding : High affinity (2:1 peptide:copper ratio) Coordination : Copper binds to nitrogen atoms from the glycine -amine, histidine imidazole, and lysine -amine The copper coordination is critical for biological activity

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