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In addition, accumulated oxygen free radicals in thyroid cells may inhibit TPO function and interfere with the synthesis and secretion of thyroid hormones, causing hypothyroidism (86)
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Metformin restores PA-impaired GLP-1R level and PKA phosphorylation in HUVECs through AMP-activated protein kinase (AMPK) pathway It has been reported that metformin exerts its multiple metabolic actions via AMPK pathway 7
Hawk E, Breslow RA, Graubard BI
Unveiling the roles of the glutathione redox system in vivo by analyzing genetically modified mice
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