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Verdict: Limited evidence the absence of human trials reflects a combination of a cancelled unpublished safety study, specific FDA-documented safety concerns, and structural barriers that make large-scale human trials difficult to initiate and fund [4][10][1415]

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If you are taking a B complex for general nutritional support and it contains adequate B12 (typically 2.550 micrograms), additional B12 supplementation may be unnecessary unless specifically indicated

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