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FDAs MRTP review framework is informed by its March 2012 draft guidance, Modified Risk Tobacco Product Applications , which remains FDAs operative guidance on the content and organization of MRTP applications and calls for a broad scientific showing addressing, among other things, product characterization, nonclinical and clinical evidence, consumer perception and understanding, actual-use behavior, population-level modeling, proposed labeling and advertising, and postmarket surveillance

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Among these product users, fruit/candy (80.7%), mint (77.4%), and menthol (67.7%) were commonly preferred flavors, while tobacco flavors were less commonly preferred (19.4%)

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