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Figure 1B shows an overview of the preclinical study design with healthy and T2DM subjects

F.Mendez-SanchezN.PortincasaP.et al

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Of cautionary note, several researchers have reported that the urinary aldehydes are unstable, 148 likely prone to oxidation, so researchers may need to test very fresh urine or determine a method to stabilize the urine sample with a nonsulfur-containing antioxidant, such as ascorbic acid, as was done for the hydroxyhemopyrrolin-2-one analysis

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