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In our study 92 , bradykinin, ATP, substance P and CGRP levels in BALF were increased in OVA mice, and these increases were augmented in OVA plus UFP-exposed mice and in NHBE cells with increasing UFP doses, suggesting that UFPs activate TRPVs and P2X7 and secrete neuromediators that lead to airway inflammation, exacerbating asthma

However, TREK-1 knockout mice are viable and generally healthy, suggesting that complete loss of TREK-1 function is tolerated