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Autosomal dominant mutations in the COL1A1 or COL1A2 genes in OI patients disrupt the synthesis and structure of type I collagen, which in turn leads to Osteogenesis Imperfecta, also known as the brittle bone disease

Interestingly, the threshold for sensory nerve stimulation and cough is reduced in the presence of inflammatory mediators, and inhalation of these mediators and low pH can induce coughing in both humans and animals

The combination of open enamel, stain-causing chemicals, and reduced oral hygiene protection makes it harder to maintain a brighter smile

Environmental Monitoring and Assessment, 154, 197-218

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