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Once malignant transformation occurs, the change is irreversible, considered cancerous, and requires treatment

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Diseases linked to chewing tobacco and related products As mentioned earlier, habitually chewing on various forms of tobacco has been linked to several diseases, such as: Mouth cancer: Users of tobacco and tobacco-based products that can be consumed orally become exposed to different kinds of cancers, primarily oral cancers of the cheeks, gums, lips, tongue or the roof or floor of the mouth

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Unlike its additive effect with diabetes on MASH-fibrosis, smoking exhibits a synergistic effect with other metabolic risk factors, such as hypertension and dyslipidemia, on the development of CVD [72,73,74]