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10.2337/dc18-0680 23 JabbourS

Notably, multiple interactions within the subnetwork converged on key AMPK regulatory nodes, including Acaca and Acacb (encoding ACC 1 and 2, respectively), Pparg (PPAR) and mammalian target of rapamycin (mTor), highlighting the intricate integration of lipid biosynthesis with energy-sensing pathways

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Cardiometabolic risk factors, such as C-reactive protein, lipids, and blood pressure, were also reduced with semaglutide treatment compared with placebo [49]

Oxygen consumption rate (OCR) The mitochondrial pressure was measured using a Seahorse XFe24 extracellular flux analyzer (Agilent Technologies)