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The FDA issued a Drug Safety Communication in 2024 stating that their review did not find clear evidence of an increased risk of suicidal thoughts or actions with GLP-1 receptor agonists, though they continue to evaluate this safety concern

Drugs that target ActRII can simultaneously inhibit fat accumulation and promote muscle growth because by blocking the signaling pathway on this receptor, which is present in both muscle and fat cells, they effectively prevent the negative regulation of muscle growth while also influencing fat metabolism, leading to a combined effect of increased muscle mass and reduced fat storage

However, side effects also depend on the dose (higher dose means higher risk of side effects)

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