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We designed the nanoparticles to effectively hold the drug and then gradually collapse, releasing it into nearby tissue in a sustained way instead of spreading the drug throughout the body quickly, says patch designer and study co-leader Zhen Gu, associate professor in the joint University of North Carolina-North Carolina State biomedical engineering department

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Patients prescribed DOACs (apixaban, rivaroxaban, edoxaban, dabigatran) require renal function monitoring at least annually, and more frequently in those aged over 75, with low body weight, intercurrent illness, or chronic kidney disease

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