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Glutamatergic and GABAergic Dysfunction A more recent hypothesis for SZ pathology involves glutamatergic dysfunction, involving the hypofunction of N -methyl-D-aspartate (NMDA) receptors of which glutamate, the major excitatory transmitter in the brain, binds (73, 74)

PubMed, Kasikara, Canan, et al

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Study selection and data extraction We included prospective cohorts with at least 50 cardiovascular disease events (mortality, morbidity, or both) to minimise the potential for reporting bias, in which large but unreliable effects might be seen in small studies