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doi: 10.1161/01.ATV.0000122852.22604.78

These combined effects make the development of DSIP a promising aid for individuals struggling with long-term pain management (5)

A shift toward pro-inflammatory immune phenotypessuch as increased M1-type macrophage infiltration and elevated levels of cytokines like Tumor necrosis factor-alpha (TNF-) and Interleukin-6 (IL-6)has been shown to inhibit osteogenesis, stimulate osteoclastogenesis, and ultimately accelerate bone loss ( Furthermore, the NF-B signaling pathway, a central mediator of inflammation, has been identified as a critical target in immunebone crosstalk

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